منابع مشابه
Rab11 in Disease Progression
Membrane/ protein trafficking in the secretory/ biosynthetic and endocytic pathways is mediated by vesicles. Vesicle trafficking in eukaryotes is regulated by a class of small monomeric GTPases the Rab protein family. Rab proteins represent the largest branch of the Ras superfamily GTPases, and have been concerned in a variety of intracellular vesicle trafficking and different intracellular sig...
متن کاملA Positive TGF-β/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer12
UNLABELLED Hepatocellular carcinoma (HCC) is globally the second most common cause of cancer mortality. The majority of HCC patients are diagnosed at advanced stage disease for which no curative treatments exist. TGF-β has been identified as a potential therapeutic target. However, the molecular mechanisms mediating its functional switch from a tumor suppressor to tumor promoter in HCC and its ...
متن کاملRegression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats
Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognos...
متن کاملThe Effect of Resveratrol Supplementation and Aerobic Exercise on Serum Levels of Activin A and TGF-β in Rats with Non-Alcoholic Fatty Liver Disease
Background & Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) is one of the main causes of abnormal liver function, and the prevalence of this disease is reported to be around 20% in the world (1). NAFLD is often associated with obesity, dyslipidemia, and insulin resistance in metabolic syndrome (2). NAFLD includes the accumulation of triglycerides, necrosis, and apoptosis in fat cells, which ar...
متن کاملTGF-β Signaling in Bone Remodeling and Osteosarcoma Progression
Osteosarcomas are the most prevalent malignant primary bone tumors in children. Despite intensive efforts to improve both chemotherapeutics and surgical management, 40% of all osteosarcoma patients succumb to the disease. Specifically, the clinical outcome for metastatic osteosarcoma remains poor; less than 30% of patients who present metastases will survive five years after initial diagnosis. ...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2011
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-011-1246-y